Watch Manchester United vs Middlesbrough Live FA cup match
Manchester United make five changes to the side that beat West Ham United 1-0 a fortnight ago. Dean HendersonDean Henderson takes the place of David de Gea in goal.
Paul Pogba returns from injury while Marcus Rashford, Luke Shaw and Jadon Sancho also step up; they replace Fred, Anthony Elanga, Alex Telles and the indefinitely suspended Mason Greenwood.
The 19-year-old Tunisia midfielder Hannibal Mejbri is named among the substitutes.
Middlesbrough make one change to the team sent out to beat Coventry City 1-0 in the Championship last weekend.
Folarin Balogun, on loan from Arsenal, comes in for Aaron Connolly up front, in a team that also includes former United defender Paddy McNair.